The best way to hit these two groups where it hurts is from their right. If you're making the case for healthcare reform with the public option, here are two winning angles:
1) Not passing a public option is the equivalent of raising taxes by $1100 per person.
2) With our current system, the same number of Americans killed on 9/11 die every two month because they’re uninsured -- or because their health insurance company screwed them. A new 9/11 every two months.
You're hitting them with the big ticket center-right issues: taxes, life & death and the 9/11 card.